Pharmacotherapy: attention must be paid to the situation of clarithromycin and its role in Helicobacter pylori eradication schemes.

Abstract

The virulence and extreme adaptability of Helicobacter Pylori as well as its direct relationship with gastric cancer, acid peptic diseases, as well as other gastrointestinal disorders with a great impact on world public health, particularly in Latin America, determine the development of research that allows improving the efficacy of eradication programs, where antimicrobial treatment schemes represent the most widely used strategy. However, resistance to antimicrobials, especially to clarithromycin, has become very relevant as a decisive factor for therapy failure, since this antibiotic is usually one of the most important recommendations in various schemes that allow the eradication of this bacterium, for Therefore, the search for strategies that reduce the possibility of failure in the pharmacological therapy to be used is a priority task. Methodology: An exhaustive search was carried out in various bibliographic sources available with open access in the Research 4 life metabase, the Chrocane collaborations database and the Pubmed NCBI metabase were consulted, Google Scholar was also consulted. Conclusions: The detection of resistance to Clarithromycin is a high-performance strategy to predict which pharmacological therapy is the most appropriate to use, since usually and empirically the task of prescribing or guiding eradication therapies is undertaken. Therefore, research and development aimed at the early detection of resistance to clarithromycin is a valuable opportunity to dramatically improve clinical outcomes.

Key words: H. pylori, clarithromycin, antibiotic resistance, acid peptic disease.