Effectiveness of Tranexamic Acid as a fibrinolysis inhibitor in patients with postpartum hemorrhage treated in a Hospital in Nicaragua

Abstract

Postpartum Hemorrhage (PPH) is defined as blood loss of 500 mL or more within 24 hours after delivery, which can be classified according to the time of occurrence, as early or late; according to the WHO, this is the main cause of maternal mortality in Latin America and worldwide.

The purpose of the study was to identify the effectiveness of tranexamic acid as a treatment in patients with postpartum hemorrhage, which will open the doors to the possible use of this drug by public and private health institutions to reduce the risk of bleeding and maternal death.

This descriptive, cross-sectional and retrospective study, developed at Hospital Alemán Nicaraguense Managua-Nicaragua, the national reference hospital, in which a non-randomized sample of 40 patients was taken, who were treated between 2021 and 2022 was taken. The mean age of the study population was 22 years (SD ±8); the main cause of hemorrhage was uterine atony (42.5%); Tranexamic acid showed its effectiveness by inhibiting fibrinolysis in 88% of the sample studied, although this sample size does not allow making a statistical inference, it opens the doors to continue investigating this field with a larger sample that confirms or rejects our results.

Keywords: Postpartum hemorrhage, tranexamic acid, effectiveness